Summary: Response to multiple microenvironmental cues and resilience to mechanical stress are essential features of trafficking leukocytes.Here, we describe unexpected role of titin (TTN), the largest protein encoded by the LED Voltmeter human genome, in the regulation of mechanisms of lymphocyte trafficking.Human T and B lymphocytes express five T
The Field Programmable Gate Array (FPGA) structure poses several constraints that make the implementation of complex asynchronous circuits such as Time–Mode (TM) circuits almost unfeasible.In particular, in Programmable Logic (PL) devices, such as FPGAs, the operation of the logic is usually synchronous with the system clock.However, it can
Abstract Background Achieving Stop Switch Wire climate neutrality in cities is a major challenge, especially in light of rapid urbanization and the urgent need to combat climate change.This paper explores the role of advanced computational methods in the transition of cities to climate neutrality, with a focus on energy supply and transportation sy
Using transposon-mediated gene-trap mutagenesis, we have generated a novel mouse mutant termed Blad (Bloated Bladder).Homozygous mutant mice die perinatally showing a greatly distended bladder, underdeveloped diaphragm and a reduction in Ceramic Metal halide total skeletal muscle mass.Wild type and heterozygote mice appear normal.Using PCR, we iden